It is a special day for Luì, who is finally about to receive his diploma as a scientist, and as always, Sofì is there by his side to support him and give him courage. Pongo, their loyal friend, certainly cannot miss the event. Once again, however, Mr. S and Perfidia will try to undermine the Me against You but Sofì, with the powers of a fairy, and Luì, with the best technology worthy of a true scientist, will give a hard time to their enemies. Something goes wrong and the magic will catapult everyone to distant places and times ... lost in time! In this magical journey, Me Against You will discover that they have new friends and will meet a new, fierce enemy. A fantastic and exciting cinema adventure for Luì and Sofì, full of surprises and with lots of fun for their little fans and all families.